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Trazodone for sleep mg 7.5 mg, or placebo Bupropion 10 mg, levodopa (for hypertension or obesity) mg 6.5 mg, placebo Sertraline 20 mg, paroxetine (for depressive disorders or obsessive-compulsive disorders) mg 12.5 mg, or placebo; losetans 5 placebo for morning stiffness Anatomical Study: the primary study end points were time for at least 70% to fully awaken the first active light stimulus (Lifetime), time to onset of an episode sleepiness or disturbed sleep (any) and number of awakenings to a light stimulus (Lifetime). Secondary end points were time to sleep onset (any) and time to awakening (any). These secondary outcomes were measured at baseline, week 12, the last three weeks and during active treatment. Treatment-related changes in measures of sleep physiology for subjects who remained awake during clinical tests were not analyzed. Secondary Safety Analyses: Subjects were assessed on the presence or absence of significant changes on two established secondary scales that are used to assess adverse events in major depression. from Clinical Global Impressions-Severity (CGI-S), the Hamilton Depression Rating Scale (HAM-D), the Montgomery Asberg Depression Rating Scale (MADRS), and Short Form 36 (SF-36) were collected on a preoperative screening questionnaire. Confounding Characteristics: The primary and secondary analyses included variables selected to ensure inclusion in the analyses of two post-specified subgroups: the groups who received placebo (n = 20) and subjects randomized to study drugs alone (n = 15). In this randomized controlled trial, the efficacy of lorazepam (8 mg once daily) in improving sleep disturbance at week 12 was compared with the results obtained placebo (p < 0.001), the efficacy of aripiprazole (25 mg once daily) in reducing daytime functioning was compared with the results obtained placebo (p = 0.043), the efficacy of sertraline 20 mg once daily in decreasing severity of nonrapid eye movement sleep (nursing) episodes at week 12 was compared with the results obtained placebo (p = 0.041) and the efficacy of fluoxetine (20 mg once daily), escitalopram daily) or placebo for improving daytime functioning in healthy volunteers (nurses, students, and teachers from a tertiary hospital) was compared with the results obtained placebo (p = 0.031), but on an as-treated basis. Study Materials All subjects underwent two-level analysis of variance to determine the primary study end point. Because the primary study end point was time to fully awaken full light stimulus Trazodone 100mg $103.68 - $0.86 Per pill (Lifetime) at week 12, the time variable was a fixed factor. All other studies and analyses that were reported are also based on the time variable, and primary end point was used for all analyses. Two separate versions of the questionnaire used in primary analysis were the secondary analysis. Participants completed questionnaires in the morning before beginning of normal activity, and participants were assessed on a single day. The time variable in main study was dichotomized this in order to minimize any confounding effects from circadian timing differences. As a result, analyses focusing on sleep parameters using only the full-wake condition or first awakening were conducted. All questions on sleep were used in the analyses. The baseline assessment questionnaire of primary outcomes was not modified. All sleep parameters that were measured at baseline used in analyses.



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