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Viagra generic medicine is an anti-depressant that's marketed primarily against female patients, but has also been shown to help alleviate the symptoms of menstrual dysfunction in some individuals.
While it's still unclear why the drug works better for women than men, one hypothesis is that the hormone progesterone — which increases during the luteal phase of menstrual cycles, and which also seems to play a role in women's sexual dysfunction — acts as a mood-elevating agent.
But that doesn't explain why it helps improve the sexual performance of men.
To find out more about the drug's effect on male sexual performance in both men and women, neuroscientist Dr. Michael Gazzaniga and his team created a computer model to evaluate the relationship between male sexual arousal and testosterone progesterone levels.
The researchers measured men's blood levels of progesterone during the first 30 minutes of sexual stimulation, as well the amount of testosterone they produced during the same period.
A comparison group of 20 healthy volunteers also was included in the assessment. As a result, researchers were able to calculate the levels of testosterone, progesterone and the other male hormones in blood and urine of the 20 volunteers and men in the computer model.
The computer modeling, published in Science and here for the first time online, revealed that the testosterone levels during first 30 minutes of sexual activity is the strongest indicator of potency female orgasm, according to the new findings.
Additionally, the researchers confirmed that both amount of progesterone and the testosterone produced after first 30 minutes of sexual stimulation had a big influence on the potency of male orgasm.
"In men, the potency of ejaculate is directly proportional to the amount of hormone secreted and to the extent that these hormonal levels are elevated," Dr. Gazzaniga said.
To further investigate the mechanisms responsible for drug's effect during sexual stimulation, the researchers decided to examine effects of the drug on neurotransmitters dopamine, norepinephrine and serotonin.
In the study, amount of dopamine, for instance, had a significant effect on the potency of male ejaculate.
While the drug, which is known as a dopamine agonist due to its ability stimulate dopamine D1 receptors, reduced the intensity of male sexual excitement, its effects on the neurotransmitters also reduced intensity of sexual desire.
"The dopamine receptor agonist modulates release, but we did not observe any effects on dopamine release in the brain regions related to arousal — such as the basal ganglia and brainstem — during ejaculation," Dr. Gazzaniga said. "However, we did observe this effect in the brain regions involved reward processing, such as the ventral striatum, suggesting that dopamine agonist modulates reward processing in the brain."
The scientists noted that dopamine agonist appeared to exert its effects on female hormones during the luteal phase of menstrual cycle, while it had no effect during the follicular phase.
The researchers explained that high intensity of sexual desire is related to high dopamine activity — which is why the drug seemed to have no effect on female hormones at low doses and an antidepressant effect at high doses.
However, at higher doses, the drug seems to have an antidepressant effect — resulting in a decrease desire and Viagra 90 Pills 100mg $129 - $1.43 Per pill overall arousal during sexual stimulation — which could have a beneficial effect on sexual functions for women, the researchers buy brand viagra online canada said.
"This would be similar to antidepressants, which are often used to relieve mood disorders such as depression," Abc online pharmacy in canada Dr. Gazzaniga said.
In addition to Dr. Gazzaniga's research, his team included a neurosurgeon, psychologist, pharmacist, and two physicians.
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